Endocrine Abstracts

Symptomatic pituitary metastasis is an uncommon presentation of primary carcinoma. We report a case of a 65 years old lady who presented with a six week history of headache and diplopia and a five day history of diarrhoea and vomiting. She also suffered from osteoporosis. She had undergone a hysterectomy for a fibroid. Examination revealed diplopia in all directions of gaze, no papilloedema and an unremarkable systemic examination. Brain MRI showed a contrast enhancing pituita...

A 41 year old male presented with erectile dysfunction associated with clinical hypogonadism (testosterone 0.8 nanomoles/litre). Hypopituitarism was confirmed on endocrine testing: Free T3 2.7 picomoles/litre, TSH 1.7 milliunits/litres, LH 0.6 units/litre, FSH 2.3 units/litre, PRL 34 units/litre, GH <0.5 milliunits/litre, IGF-1 10.5 nanomoles/litre, flat response of LH and FSH to Gn-RH, GH <0.5 milliunits/litre throughout ITT. (Cortisol rose from 197 to 523 nanomoles/lit...

Introduction: Diseases of the hypothalamus/pituitary are complex and can be difficult to diagnose. Diagnostic possibilities are many and include sphenoid ridge meningiomas and aneurysms of the internal carotid artery as well as craniopharyngiomas, gliomas of the optic nerve, inflammatory and granulomatous disease.Case report: We present two cases to illustrate the complex differential diagnosis.The first patient presented with head...

A 32 year old man with a history of epilepsy since childhood presented in 1992 with a grand mal seizure and clinical features of tuberous sclerosis (TSC). One year later he was referred with classical Cushingoid features. His serum Na was 140 mmol/l, K 3.4 mmol/l, 9 AM cortisol 1018 nmol/l with lack of diurnal variation and ACTH 42-50 ng/l. Urinary cortisol: 797 nmol/24 h. After overnight, low and high dose dexamethasone suppression, cortisol was 1018, 1154, and 62 nmol/l resp...